• Diarrhea
• Urinary tract infection

Klebsiella Pneumoniae

• Pneumonia
• Bloodstream infection
• The wound of surgical site infection
• Meningitis
• UTI(Mainly catheterize women)

Proteus mirabilis

• UTI

Salmonella spe Shigella spe

• GI tract infection

Staphylococcus Aureus

• Skin infection(Boil and Impetigo)
• Septicemia
• Pneumonia

Neisseria gonorrhea

• Infects mucous membranes of the reproductive tract
• Infects Urethra in women and men

Haemophilus Influenzae

• Pneumonia
• Bacteraemia
• Meningitis
• Epiglottitis
• Cellulite
• Infectious arthritis
• Ear infection in children
• Bronchitis in adult
• UTI

Dose – 750 mg IV

Drug Given – 1 to 8 hours before delivery

Effect

1. Cross Placenta
2. Maternal plasma(0-24mcg/dl)
3. amniotic) fluid (1.2-18mcg/dl)
4. umbilical cord (2-11mcg/dl)

Dose– 750 mg IV

Duration– 1985 to 1992

Drug Given – 1 to 8 hours before delivery

Out Come – No association between

• Nitrogen foil pack
• Hydrophilic polymer coating
• Manufacture in cephalosporin independent plant